Submission Deadline: 31 March 2026 (Status: Open)
Special Issue Editor(s)
Dr. Alfredo Cruz Gregorio
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Email 2
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Website
Departamento de Fisiología, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, Mexico City, Mexico
Interests:
cancer; cardio-oncology; myocardial ischemia; myocardial reperfusion; ferroptosis; treatments related to ferroptosis; oxidative stress; mitochondrial dynamics
Special Issue Information
Dear Colleagues,
According to emerging evidence, cancer is pathologically associated with cardiovascular disease (CVD). A five-tier classification system for characterizing cardio-oncology syndromes (COS) that reflect various facets of their complex interplay has been introduced:
• Type I COS, which characterizes mechanisms through which the onset or rapid progression of malignancy contributes to cardiovascular dysfunction.
• Type II COS, which deciphers the cardiotoxic effects of cancer therapies, which may result in both acute and chronic forms of CVD.
• Type III COS, which accounts for the pro-oncogenic milieu shaped by cardiokine secretion and heightened oxidative stress in individuals with existing cardiovascular pathology.
• Type IV COS, which highlights cardiovascular interventions—therapeutic and diagnostic—that may inadvertently promote or reveal underlying malignancies.
• Type V COS, which captures systemic and genetic determinants that predispose individuals to both cancer and CVD.
Across these syndromes, mitochondrial metabolism and redox balance emerge as pivotal factors. A deeper understanding of these processes may reveal novel therapeutic targets that can simultaneously enhance oncological outcomes and fortify cardiovascular health, enabling more tailored and effective interventions aligned with the specific COS subtype.
Dr. Alfredo Cruz Gregorio
Guest Editor
Keywords
cancer; cardiovascular diseases; cardio-oncological syndromes; mitochondria; reactive oxygen species; oxidative stress; ferroptosis; cell death
Manuscript Submission Information
Manuscripts should be submitted via our online editorial system at https://www.discovmed.com/Journalx_dm/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.
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