Volume 37, Issue 201 (October 2025)

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Discovery Medicine

Print ISSN: 1539-6509Online ISSN: 1944-7930

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Volume 37, Issue 201 (October 2025)

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Untangling the Mechanisms of Proteasome Inhibitor Resistance in Multiple Myeloma

Cameron Van Cleave, Brendan H. Saunders, Giada Bianchi

DM 2025, 37(201), 2072-2088; https://doi.org/10.24976/Discov.Med.202537201.178

(This article belongs to the Special Issue Molecular Mechanisms and Biomarkers in Multiple Myeloma and Lymphoma)

Mechanistic Insights Into the Periodontal-Atherosclerotic Axis: From Oral Inflammation to Cardiovascular Pathology

Dragana Stanisic, Neda Perunovic, Milica Djurdjevic, Koushik Sen, Avisek Majumder, Suravi Majumder

DM 2025, 37(201), 2089-2105; https://doi.org/10.24976/Discov.Med.202537201.179

Research Progress on the Epidemiology and Intervention Strategies for Viral Skin Diseases

Zhenjun Liu, Zhenting Liu, Xiaoqian Yu

DM 2025, 37(201), 2106-2118; https://doi.org/10.24976/Discov.Med.202537201.180

Influenza A Virus Non-structural 1 Protein: A Key Viral Weapon Against Host Pathways

Matloob Husain

DM 2025, 37(201), 2119-2134; https://doi.org/10.24976/Discov.Med.202537201.181

Real-World Lung Cancer Cell Lines for Preclinical Development and Testing of Therapeutics

Sandra Stickler, Marie-Therese Eggerstorfer, Maximilian Hochmair, Gerhard Hamilton

DM 2025, 37(201), 2135-2144; https://doi.org/10.24976/Discov.Med.202537201.182

Migraine: A Multifaceted Disorder Involving Neuroinflammation, Environmental Triggers, Treatment Strategies, and Machine Learning-Based Diagnosis

Muhammad Asif, Nelofer Jamil, Maryam Zain, Mahmood Rasool

DM 2025, 37(201), 2145-2158; https://doi.org/10.24976/Discov.Med.202537201.183

Targeting Lipids Interactions With the Immune System, Inflammatory Response, Cardiovascular Outcomes, and Their Role in Tumorigenesis

Sandra Guzmán-Silahua, Pedro Misael Ruiz-Alonso, José Antonio Robles-Cervantes, Maria G. Zavala-Cerna, Eduardo Chuquiure-Valenzuela, Kimberly Estefanía Ontiveros-Cortez, Ana Valeria Padilla-Pedroza, Jennyfer Alessandra Orozco-Franco, Benjamín Rubio-Jurado, Arnulfo Hernán Nava-Zavala

DM 2025, 37(201), 2159-2177; https://doi.org/10.24976/Discov.Med.202537201.184

(This article belongs to the Special Issue Exploring the Tumor Microenvironment: Innovations and Challenges in Enhancing Immunotherapy Efficacy)

Targeting BTRC to Restore ULK1-Mediated Autophagy in Macrophages: A Novel Strategy Against Post-Traumatic Bacterial Pneumonia

Limei Tian, Lishan Zhang

DM 2025, 37(201), 2178-2191; https://doi.org/10.24976/Discov.Med.202537201.185

Right-Sided Stellate Ganglion Block Ameliorates Insomnia-Induced Neuronal Damage and Cognitive Impairment by Suppressing Ferroptosis via NRF2/GPX4 Pathway

Meiyue Liu, Xi Ouyang, Yun Shao, Qing Zhang

DM 2025, 37(201), 2192-2204; https://doi.org/10.24976/Discov.Med.202537201.186

Exploring Correlation Between Alkaline Phosphatase and Venous Thromboembolism in East Asian Populations: A Cohort and Mendelian Randomization Study

Haichao Wu, Haobo Li, Tao Wang, Zhongtiao Xu, Haiwei Chu, Long Zhou, Qiang Wang, Zhu Zhang, Zhenguo Zhai, Siyuan Liang

DM 2025, 37(201), 2205-2213; https://doi.org/10.24976/Discov.Med.202537201.187

Angelicin Mitigating Renal Fibrosis and Treating IgA Nephropathy via the ESR1-FOS Pathway

Hejing Fang, Ling Zhou, Xuchun Xu, Tingting Zhang, Shuangqing Li, Can Jin

DM 2025, 37(201), 2214-2223; https://doi.org/10.24976/Discov.Med.202537201.188

FGF19 Alleviates Cortisol-Induced Mitochondrial Damage and Apoptosis in Human Cardiomyocytes

Jingxian Zhang, Xiaoping Meng

DM 2025, 37(201), 2224-2234; https://doi.org/10.24976/Discov.Med.202537201.189

LASP2 Knockdown Inhibits High Glucose-Induced Suppression of Trophoblast Cell Proliferation and Migration During Gestational Diabetes Mellitus

Yan Huang, Jianmei Ling, Lingyu Zhang, Mingjin Zhang

DM 2025, 37(201), 2235-2243; https://doi.org/10.24976/Discov.Med.202537201.190

From Lipoxygenase to Lineage Fate: ALOX5 Drives Thyroid Cancer Progression via the Jagged1-Notch Axis–Mediated M2 Macrophage Polarization

Shangwei Li, Xiao Lin

DM 2025, 37(201), 2244-2255; https://doi.org/10.24976/Discov.Med.202537201.191

TRPML1 Modulates Calcium Signaling to Coordinate Mitochondria–Lysosome Crosstalk in Spinal Cord Injury Repair

Jinglong Zhang, Jing Kong, Zhiyong Zhao, He Zhang, Ruobing Bai, Shuai Yuan

DM 2025, 37(201), 2256-2268; https://doi.org/10.24976/Discov.Med.202537201.192

Mechanisms of Allicin Improving Immunotherapy in Non-Small Cell Lung Cancer by Modulating KDM5B/SETDB1 Axis

Cheng Chen, Weina Li, Yiling Jiang, Guofei Ren, Hongjin Yu, Jing Fang

DM 2025, 37(201), 2269-2282; https://doi.org/10.24976/Discov.Med.202537201.193

Association Between Polypharmacy and Gait Performance in Older Adults With Cerebral Small Vessel Disease

Wei Wei, Hong-yang Xie, Cui-qiao Xia, Nan Zhang, Jun-jie Cao, Hong-yi Zhao, Yong-hua Huang

DM 2025, 37(201), 2283-2293; https://doi.org/10.24976/Discov.Med.202537201.194

PBMC-derived DECR1 Inhibits Ferroptosis of Macrophages by Activating Catalase to Confer Cardiac Protection in Septic Myocardial Injury

Wei Zhang, Zhizhen Lai, Lisha Pang, Muhua Dai, Jianbiao Meng

DM 2025, 37(201), 2294-2308; https://doi.org/10.24976/Discov.Med.202537201.195

TSP-1 Promotes Bone Healing via Angiogenesis and MSC Recruitment in Rat Fractures

Chengbo Wu, Xing Lu, Xiliang Zang

DM 2025, 37(201), 2309-2319; https://doi.org/10.24976/Discov.Med.202537201.196

EPA-Induced Gut Microbiota Remodeling Restores Mitochondrial Function and Enhances Efferocytosis to Combat Atherosclerosis

Yiqiu Zhou, Si Chen, Jianing Li, Decai Zhu

DM 2025, 37(201), 2320-2333; https://doi.org/10.24976/Discov.Med.202537201.197

Risk of Bladder Cancer Based on Genetic Background of the Han Chinese Population

Yaqin Fan, Qingcheng Gao, Guangtao Xu, Deqing Chen, Yigang Jin, Chenye Tang, Chun Sun, Dandan Cai, Fei Wang

DM 2025, 37(201), 2334-2348; https://doi.org/10.24976/Discov.Med.202537201.198

Role of the TLR-4/NF-κB Signaling in Cochlear Inflammation and Its Therapeutic Potential for Age-Related Hearing Loss

Yubiao Liu, Hui Zhao, Hongmei Zhu, Yongjiu Huang

DM 2025, 37(201), 2349-2359; https://doi.org/10.24976/Discov.Med.202537201.199

Forkhead Box Protein 1 Protects the Glycocalyx and Mitigates COPD by Suppressing MMP9

Fan Zhou, Yajie Shi, Yu Wang, Xiaolong He

DM 2025, 37(201), 2360-2370; https://doi.org/10.24976/Discov.Med.202537201.200

Individual-Patient Networks Inform Patient-Level Differences in Phenotype and Delineate Key Candidate Genes and Signaling Pathways in PCOS Granulosa Cells

Fan Zhang, Yi-hua Chen, Li-li Sun, Wei Wei

DM 2025, 37(201), 2371-2387; https://doi.org/10.24976/Discov.Med.202537201.201

STING/CXCL10 Axis Inhibits Macrophage M2 Polarization and BMCs Differentiation in Lung Cancer Cells

Haijian Liu, Danfei Zhou, Jiaojiao Ren, Jiangdong Li, Shanshan Hu, Jun Ying

DM 2025, 37(201), 2388-2399; https://doi.org/10.24976/Discov.Med.202537201.202

The Therapeutic Effect of siRNA Formulation That Inhibits Vascular Endothelial Growth Factor on Retinal Neovascularization

Li Li, Huanzhang Xia

DM 2025, 37(201), 2400-2410; https://doi.org/10.24976/Discov.Med.202537201.203

Histone Lactylation Promotes Transcriptional Activation of YTHDF2 in High Glucose-Induced Renal Injury by Enhancing m6A Modification of GDF15

Rucui Yu, Xingxing Wang, Tingting Chen, Jingwei Xu

DM 2025, 37(201), 2411-2427; https://doi.org/10.24976/Discov.Med.202537201.204

Targeting Inflammatory and Fibrotic Responses: Butorphanol Orchestrates Wound Healing by Suppressing the IL-6/p38/JNK Pathway

Minlie Yang, Yang Yang, Gaofeng Shi, Yun Guo, Tianfan Xuan, Dan Sun, Lingtao Ding, Xian Ding

DM 2025, 37(201), 2428-2438; https://doi.org/10.24976/Discov.Med.202537201.205

The Role and Underlying Mechanism of the MCP-1/CCR2 Signaling Pathway in the Inflammatory Response of Atopic Dermatitis Pathogenesis

Jieyu Chen, Mian Xu

DM 2025, 37(201), 2439-2454; https://doi.org/10.24976/Discov.Med.202537201.206

Sodium Hydrosulfide Alleviates Osteoporosis by Suppressing Osteoclastogenesis via the Inhibition of the NF-κB Signaling

Wenqing Tong, Wenchao Fei, Ke Xu, Yang Hong, Yinghua Li

DM 2025, 37(201), 2455-2474; https://doi.org/10.24976/Discov.Med.202537201.207

LGR4 Promotes Lung Adenocarcinoma Progression via Activation of the NF-κB Signaling Pathway

Lu Li, Chengcheng Yang, Xiaowen Kang, Zhaoguo Li, Kun Huang, Wei Zhang

DM 2025, 37(201), 2475-2487; https://doi.org/10.24976/Discov.Med.202537201.208