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Discovery Medicine

Print ISSN: 1539-6509Online ISSN: 1944-7930

Impact Factor: 2.1

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About Discovery Medicine

Discovery Medicine is a peer-reviewed academic journal indexed in the Science Citation Index Expanded (SCI-E) of Web of Science. The journal publishes research in the field of medicine, with a particular focus on advancing the understanding of physiological and pathological mechanisms in human health and disease, as well as on the development, improvement, and clinical evaluation of strategies for disease prevention, diagnosis, and treatment.

It aims to provide a global platform for researchers and clinicians to disseminate impactful findings and to facilitate the continuous advancement of medical research and clinical practice. More about Discovery Medicine.

About Discovery Medicine

Discovery Medicine is a peer-reviewed academic journal indexed in the Science Citation Index Expanded (SCI-E) of Web of Science. The journal publishes research in the field of medicine, with a particular focus on advancing the understanding of physiological and pathological mechanisms in human health and disease, as well as on the development, improvement, and clinical evaluation of strategies for disease prevention, diagnosis, and treatment.

It aims to provide a global platform for researchers and clinicians to disseminate impactful findings and to facilitate the continuous advancement of medical research and clinical practice. More about Discovery Medicine.

Editorial Board

  • Portrait of Editorial Board member Jun-Li Liu

    Jun-Li Liu

    Editor-in-Chief

    gene targeting and transgenic overexpression in mice; pancreatic islet growth and protection; metabolic regulation and the mechanism of diabetes mellitus

  • Portrait of Editorial Board member Anne Vejux

    Anne Vejux

    Associate Editor-in-Chief

    oxysterols; very-long chain fatty acids; lipid metabolism; peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases; diet; brain

  • Portrait of Editorial Board member Diana Amantea

    Diana Amantea

    Editorial Board Member

    cerebral ischemia; neuro-immune interactions; neuroinflammation; neuroprotection; stroke

  • Portrait of Editorial Board member Fernando A. Arosa

    Fernando A. Arosa

    Editorial Board Member

    human CD8+ T cells; effector-memory; HLA class I; IL-15; tissue repair; neuroregeneration; cognition

Highlights

Review
Neuroinflammation in the Post-Ischemic Brain in the Presence of Amyloid and Tau Protein

Ryszard Pluta

DM 2025, 37(192), 1-18; https://doi.org/10.24976/Discov.Med.202537192.1

23 Views
24 Downloads
17 Citations
Editorial
Antimicrobial Resistance: A Global Public Health Concern that Needs Perspective Combating Strategies and New Talented Antibiotics

Abdelazeem Mohamed Algammal, Payam Behzadi

DM 2024, 36(188), 1911-1913; https://doi.org/10.24976/Discov.Med.202436188.177

71 Views
25 Downloads
47 Citations
Article
Thermoresponsive and Injectable Pluronic F127 Hydrogel for Loading Adipose-Derived Mesenchymal Stem Cells

Khan Sharun, Shajahan Amitha Banu, Merlin Mamachan, Rony S. Emmanuel, Rohit Kumar, Obli Rajendran Vinodhkumar, Kuldeep Dhama, Abhijit Motiram Pawde, Swapan Kumar Maiti, Amar Pal

DM 2024, 36(181), 294-307; https://doi.org/10.24976/Discov.Med.202436181.28

100 Views
30 Downloads
19 Citations
Review
Growth Differentiation Factor-15 Orchestrates Inflammation-Related Diseases via Macrophage Polarization

Jingjing Huang, Xinhuan Ding, Yuan Dong, Haiyan Zhu

DM 2024, 36(181), 248-255; https://doi.org/10.24976/Discov.Med.202436181.23

66 Views
86 Downloads
22 Citations

Article List

Latest Issue
Top Read
Article
Esketamine Protects Against Sepsis-Induced Intestinal Injury by Modulating Macrophage Polarization Through the TLR4/NF-κB Signaling Pathway

Liyan Miao, Li Zhang, Min Zhou, Qiuchun Chen

DM 2026, 38(208), 1661-1672; https://doi.org/10.24976/Discov.Med.202638208.130

97 Views
83 Downloads
Article
Predictive Value of CRP/Albumin Ratio For Treatment Response to PTGBD in Patients With High-Risk Acute Cholecystitis

Chuncui Ye, Anqing Luo, Jun Wang

DM 2026, 38(208), 1649-1660; https://doi.org/10.24976/Discov.Med.202638208.129

91 Views
33 Downloads
Article
Hypoxia Bone Marrow Mesenchymal Stem Cell-derived Exosomal AHCY Facilitates the Development of Lung Cancer via MCCC2-activated ERK Pathway

Bing Han, Feifei Ma, Junhua Hu, Zhenzhen Zheng, Chao Su, Xinnan Song

DM 2026, 38(208), 1635-1648; https://doi.org/10.24976/Discov.Med.202638208.128

61 Views
39 Downloads
Article
A Retrospective Study on the Diagnostic Efficacy of Bone Turnover Markers Combined With Inflammatory Indicators in Elderly Patients With Chronic Kidney Disease for Osteoporosis

Yangchang Chen, Suping Li, Zhenmu Jin, Xiaozuo Xu, Yingying Gong, Xuewei Cao, Qiong Wu

DM 2026, 38(208), 1627-1634; https://doi.org/10.24976/Discov.Med.202638208.127

80 Views
45 Downloads
Article
RNA Binding Motif Protein 15 Regulates GTPase Activating Rap/RanGAP Domain Like 3 Gene Expression as a Potential Mechanism of Temozolomide Resistance in Glioblastoma With Epidermal Growth Factor Receptor vIII Mutation

Guoxuan Luo, Sijia Cheng, Yang Zhang, Jiawen Liu, Tingting Luo, Jiayi Li, Yunzhi Ling, Jianjun Lu

DM 2026, 38(208), 1610-1626; https://doi.org/10.24976/Discov.Med.202638208.126

58 Views
89 Downloads
Article
Unveiling the Power of Astragaloside IV: A Novel Approach to Modulating KGN Cell Proliferation and Glycolysis Through the PPARγ/GNB2/PKM2 Axis

Wenchao Zhang, Shuzhen Zhang, Bin Wang, Jun Jiang, Mingxiao Wen

DM 2026, 38(208), 1597-1609; https://doi.org/10.24976/Discov.Med.202638208.125

52 Views
47 Downloads
Article
Esketamine Alleviates Limb Ischemia-Reperfusion-Induced Lung Injury by Inducing Macrophage Polarization

Meng Wang, Wenjuan Wang, Peng Wang, Heng Wen, Jiawei Cun, Qian Ma

DM 2026, 38(208), 1583-1596; https://doi.org/10.24976/Discov.Med.202638208.124

6 Views
41 Downloads
Article
Regulatory Mechanism of SREBP1-Mediated Lipid Metabolic Remodeling in Osteoclast Differentiation

Xiaojun Li, Bingjian Lin, Fayi Li, Nan Zhou

DM 2026, 38(208), 1570-1582; https://doi.org/10.24976/Discov.Med.202638208.123

45 Views
66 Downloads

Special Issue

About Discovery Medicine

Discovery Medicine is a peer-reviewed academic journal indexed in the Science Citation Index Expanded (SCI-E) of Web of Science. The journal publishes research in the field of medicine, with a particular focus on advancing the understanding of physiological and pathological mechanisms in human health and disease, as well as on the development, improvement, and clinical evaluation of strategies for disease prevention, diagnosis, and treatment.

It aims to provide a global platform for researchers and clinicians to disseminate impactful findings and to facilitate the continuous advancement of medical research and clinical practice. More about Discovery Medicine.

About Discovery Medicine

Discovery Medicine is a peer-reviewed academic journal indexed in the Science Citation Index Expanded (SCI-E) of Web of Science. The journal publishes research in the field of medicine, with a particular focus on advancing the understanding of physiological and pathological mechanisms in human health and disease, as well as on the development, improvement, and clinical evaluation of strategies for disease prevention, diagnosis, and treatment.

It aims to provide a global platform for researchers and clinicians to disseminate impactful findings and to facilitate the continuous advancement of medical research and clinical practice. More about Discovery Medicine.

Editorial Board

  • Portrait of Editorial Board member Jun-Li Liu

    Jun-Li Liu

    Editor-in-Chief

    gene targeting and transgenic overexpression in mice; pancreatic islet growth and protection; metabolic regulation and the mechanism of diabetes mellitus

  • Portrait of Editorial Board member Anne Vejux

    Anne Vejux

    Associate Editor-in-Chief

    oxysterols; very-long chain fatty acids; lipid metabolism; peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases; diet; brain

  • Portrait of Editorial Board member Diana Amantea

    Diana Amantea

    Editorial Board Member

    cerebral ischemia; neuro-immune interactions; neuroinflammation; neuroprotection; stroke

  • Portrait of Editorial Board member Fernando A. Arosa

    Fernando A. Arosa

    Editorial Board Member

    human CD8+ T cells; effector-memory; HLA class I; IL-15; tissue repair; neuroregeneration; cognition

Highlights

Review
Neuroinflammation in the Post-Ischemic Brain in the Presence of Amyloid and Tau Protein

Ryszard Pluta

DM 2025, 37(192), 1-18; https://doi.org/10.24976/Discov.Med.202537192.1

23 Views
24 Downloads
17 Citations
Editorial
Antimicrobial Resistance: A Global Public Health Concern that Needs Perspective Combating Strategies and New Talented Antibiotics

Abdelazeem Mohamed Algammal, Payam Behzadi

DM 2024, 36(188), 1911-1913; https://doi.org/10.24976/Discov.Med.202436188.177

71 Views
25 Downloads
47 Citations
Article
Thermoresponsive and Injectable Pluronic F127 Hydrogel for Loading Adipose-Derived Mesenchymal Stem Cells

Khan Sharun, Shajahan Amitha Banu, Merlin Mamachan, Rony S. Emmanuel, Rohit Kumar, Obli Rajendran Vinodhkumar, Kuldeep Dhama, Abhijit Motiram Pawde, Swapan Kumar Maiti, Amar Pal

DM 2024, 36(181), 294-307; https://doi.org/10.24976/Discov.Med.202436181.28

100 Views
30 Downloads
19 Citations
Review
Growth Differentiation Factor-15 Orchestrates Inflammation-Related Diseases via Macrophage Polarization

Jingjing Huang, Xinhuan Ding, Yuan Dong, Haiyan Zhu

DM 2024, 36(181), 248-255; https://doi.org/10.24976/Discov.Med.202436181.23

66 Views
86 Downloads
22 Citations

Article List

Latest Issue
Top Read
Article
Esketamine Protects Against Sepsis-Induced Intestinal Injury by Modulating Macrophage Polarization Through the TLR4/NF-κB Signaling Pathway

Liyan Miao, Li Zhang, Min Zhou, Qiuchun Chen

DM 2026, 38(208), 1661-1672; https://doi.org/10.24976/Discov.Med.202638208.130

97 Views
83 Downloads
Article
Predictive Value of CRP/Albumin Ratio For Treatment Response to PTGBD in Patients With High-Risk Acute Cholecystitis

Chuncui Ye, Anqing Luo, Jun Wang

DM 2026, 38(208), 1649-1660; https://doi.org/10.24976/Discov.Med.202638208.129

91 Views
33 Downloads
Article
Hypoxia Bone Marrow Mesenchymal Stem Cell-derived Exosomal AHCY Facilitates the Development of Lung Cancer via MCCC2-activated ERK Pathway

Bing Han, Feifei Ma, Junhua Hu, Zhenzhen Zheng, Chao Su, Xinnan Song

DM 2026, 38(208), 1635-1648; https://doi.org/10.24976/Discov.Med.202638208.128

61 Views
39 Downloads
Article
A Retrospective Study on the Diagnostic Efficacy of Bone Turnover Markers Combined With Inflammatory Indicators in Elderly Patients With Chronic Kidney Disease for Osteoporosis

Yangchang Chen, Suping Li, Zhenmu Jin, Xiaozuo Xu, Yingying Gong, Xuewei Cao, Qiong Wu

DM 2026, 38(208), 1627-1634; https://doi.org/10.24976/Discov.Med.202638208.127

80 Views
45 Downloads
Article
RNA Binding Motif Protein 15 Regulates GTPase Activating Rap/RanGAP Domain Like 3 Gene Expression as a Potential Mechanism of Temozolomide Resistance in Glioblastoma With Epidermal Growth Factor Receptor vIII Mutation

Guoxuan Luo, Sijia Cheng, Yang Zhang, Jiawen Liu, Tingting Luo, Jiayi Li, Yunzhi Ling, Jianjun Lu

DM 2026, 38(208), 1610-1626; https://doi.org/10.24976/Discov.Med.202638208.126

58 Views
89 Downloads
Article
Unveiling the Power of Astragaloside IV: A Novel Approach to Modulating KGN Cell Proliferation and Glycolysis Through the PPARγ/GNB2/PKM2 Axis

Wenchao Zhang, Shuzhen Zhang, Bin Wang, Jun Jiang, Mingxiao Wen

DM 2026, 38(208), 1597-1609; https://doi.org/10.24976/Discov.Med.202638208.125

52 Views
47 Downloads
Article
Esketamine Alleviates Limb Ischemia-Reperfusion-Induced Lung Injury by Inducing Macrophage Polarization

Meng Wang, Wenjuan Wang, Peng Wang, Heng Wen, Jiawei Cun, Qian Ma

DM 2026, 38(208), 1583-1596; https://doi.org/10.24976/Discov.Med.202638208.124

6 Views
41 Downloads
Article
Regulatory Mechanism of SREBP1-Mediated Lipid Metabolic Remodeling in Osteoclast Differentiation

Xiaojun Li, Bingjian Lin, Fayi Li, Nan Zhou

DM 2026, 38(208), 1570-1582; https://doi.org/10.24976/Discov.Med.202638208.123

45 Views
66 Downloads

Special Issue