Volume 38, Issue 207 (April 2026)

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Discovery Medicine

Print ISSN: 1539-6509Online ISSN: 1944-7930

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Volume 38, Issue 207 (April 2026)

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Glutathione Depletion in Major Depressive Disorder and Its Impact on Tuberculosis Immunity

Marriam Anjum, Mariam Habbak, Farah Mawlawi, Aemen Siddiqui, Vishwanath Venketaraman

DM 2026, 38(207), 975-986; https://doi.org/10.24976/Discov.Med.202638207.79

The Main Molecular Mechanisms and Key Signaling Pathways of Ferroptosis

Renhe Lu, Longlong Su, Yong Ma, Hang Wang, Yu Shi, Xu Ma, Longcheng Shang, Shaozhong Ni

DM 2026, 38(207), 987-1006; https://doi.org/10.24976/Discov.Med.202638207.80

The Impact of Viral Immune Evasion on the Development of Childhood Cancer: The Role of Cytomegalovirus

Pamela Ruvalcaba-Hernández, Juan Carlos Nuñez-Enriquez, Minerva Mata-Rocha, Elva Jiménez-Hernández, Juan Manuel Mejía-Aranguré, Silvia Patricia Melchor-Doncel, Angélica Rangel-López, Juan Xicohtencatl-Cortes, SA Ochoa, Ariadnna Cruz-Cordova, José Arellano-Galindo

DM 2026, 38(207), 1007-1026; https://doi.org/10.24976/Discov.Med.202638207.81

(This article belongs to the Special Issue Exploring the Tumor Microenvironment: Innovations and Challenges in Enhancing Immunotherapy Efficacy)

Sleep Deprivation and Microglia-Dependent Synaptic Remodeling in Psychiatric Disorders

Yuyang Liu, Yingkun Sun, Ye Wang, Hong Yu, Lili Huang

DM 2026, 38(207), 1027-1038; https://doi.org/10.24976/Discov.Med.202638207.82

Multidisciplinary Management of Pediatric Obstructive Sleep Apnea: From Diagnosis to Long-Term Follow-Up

Lei Nie, Hui Li, Tiecheng Zhang, Liang Zhang, Yu Liu, Ziwei Chen, Jinsheng Hao

DM 2026, 38(207), 1039-1053; https://doi.org/10.24976/Discov.Med.202638207.83

Prophylactic PEPITEM Administration Reduces Expression of Chemokine Signaling and T-cell Migration Genes in Experimental Autoimmune Encephalomyelitis Model: RT² Profiler™ PCR Arrays

Mohammed Alassiri, Aiman Saud Alhazmi, Fahd Al Sufiani, Bahauddeen M. Alrfaei, Hasan Alnakhli, Mohammed Alasseiri, Abdullah Alamri, Jilani Shaik, Mohammad Alanazi, Mashan L. Abdullah

DM 2026, 38(207), 1054-1063; https://doi.org/10.24976/Discov.Med.202638207.84

Characteristics of Lymphatic Metastasis in Young Patients With Thyroid Carcinoma: Immunobiological and Epidemiological Perspectives

Liu-han Chen, Jia-dai Tang, Tao Xie, Qian Lei, Chuan-zheng Sun

DM 2026, 38(207), 1064-1074; https://doi.org/10.24976/Discov.Med.202638207.85

Protection of N-Butylphthalide in Ischemic Stroke: Ameliorating Neuronal Ferroptosis by Regulating the GSK-3β/NRF2 Pathway

Yuhuan Cui, Youtao Zhang, Jiahong Wu, Li Zuo, Yuanxiang Hu, Huihui Liu, Shuxian Jia, Juan Yan, Shutie Li, Zhankuang Liu

DM 2026, 38(207), 1075-1083; https://doi.org/10.24976/Discov.Med.202638207.86

Cross-tissue Gene Expression Analysis of Methotrexate Response in Rheumatoid Arthritis

Rania Magadmi

DM 2026, 38(207), 1084-1091; https://doi.org/10.24976/Discov.Med.202638207.87

(This article belongs to the Special Issue Novel Biomarkers and Therapeutic Targets for Chronic Diseases in Precision Medicine)

Preoperative NPAR-based Nomogram Models for Predicting Lymph Node Metastasis and Postoperative Gastrointestinal Function Recovery in Colorectal Cancer

Chaoqian Wang, Zhiang Li, Zhang Du

DM 2026, 38(207), 1092-1102; https://doi.org/10.24976/Discov.Med.202638207.88

HDAC2-STAT1 Axis Mediates the Protective Effect of Acetate in DNCB-Induced Atopic Dermatitis

Xiaoyan He, Xin Li, Haiyan Feng

DM 2026, 38(207), 1103-1114; https://doi.org/10.24976/Discov.Med.202638207.89

A CD40LG-Centered 6-Gene Risk Model for Survival Stratification and Immunotherapy Benefit Prediction in Ovarian Cancer

Yuan Gao, Mingxia Ye, Yawen Wu, Liang Wen, Li-An Li, Yuanguang Meng

DM 2026, 38(207), 1115-1130; https://doi.org/10.24976/Discov.Med.202638207.90

CYP26A1 as a New Prognostic Biomarker With Immune Infiltration in Thyroid Cancer

Tingting Cui, Ying Zhang, Weida Liu, Danzhen Zhang, Haiying Gong

DM 2026, 38(207), 1131-1147; https://doi.org/10.24976/Discov.Med.202638207.91

Depletion of YTHDF1 Mitigates ox-LDL-Induced Human Coronary Endothelial Cell Dysfunction by Decreasing BACH1

Lina Fang, Rui Yan, Xiaozhen Chen, Yunfu Yu, Min Zheng, Jifeng Yan

DM 2026, 38(207), 1148-1162; https://doi.org/10.24976/Discov.Med.202638207.92

SRSF1 Expression in the Endometrial Carcinoma Microenvironment: Association With Macrophage Efferocytosis and Implications for Tumor Progression

Ao Zhang, Yang Gao, Rui Fang, Zheng Li, Qing Zhu

DM 2026, 38(207), 1163-1179; https://doi.org/10.24976/Discov.Med.202638207.93

Notoginsenoside R1 Restores Endothelial Progenitor Cells Function to Relieve Atherosclerosis by Inhibiting STAT3-Mediated HPSE Transcription

Fang Fang

DM 2026, 38(207), 1180-1194; https://doi.org/10.24976/Discov.Med.202638207.94

A Novel Nomogram Based on ALBI Grade and Dynamic SII for Predicting Prognosis of Unresectable HCC Treated With TACE Plus Toripalimab

Yanjun Pu, Fen He, Xuyin Wang, Tong Lu, Jing Wang

DM 2026, 38(207), 1195-1209; https://doi.org/10.24976/Discov.Med.202638207.95

Peripheral CD4+/CD8+ T-Cell Ratio Inversely Correlates With Clinical Severity in Pediatric Mycoplasma pneumoniae Pneumonia

Yu Chen, Rui Huang, Min Zhang, XingQian Lai, Ling Chen

DM 2026, 38(207), 1210-1218; https://doi.org/10.24976/Discov.Med.202638207.96

Driven by Regulation of the NOX4/ROS/NF-κB Signaling Cascade, Angiopoietin-1 Emerges as a Potent Modulator of Post-Surgical Pain

Feifei Ma, Bing Han, Xiufang Wang, Lulu Liu, Mengmeng Li, Junhua Hu, Xinnan Song

DM 2026, 38(207), 1219-1229; https://doi.org/10.24976/Discov.Med.202638207.97

The Amyloid β Precursor Protein-CD74 Axis Mediates Intercellular Communication Between GABBR1^hiCHRM3^hi Neuron-like Cells and RYR1⁺ESRRG⁺BICC1⁺ Macrophages, Influencing Inflammatory Responses in Diabetic Nephropathy

Juan Li, YanLi Zhou, HuiYuan Li, Wei Feng, ZePei Qiu, HuanHuan Chen, XuFang Wu, JiaEr Ke, HaiQi Qin, XiangXin Meng

DM 2026, 38(207), 1230-1250; https://doi.org/10.24976/Discov.Med.202638207.98

Diversity of the Duffy Blood Group Gene (DARC/ACKR1) and Its Association With the Risk of Developing Coronary Artery Disease

Malik A. Altayar, Rashid Mir, Mohammed M. Jalal, Jamsheed Javid, Mohammad Fahad Ullah, Adil Yousif

DM 2026, 38(207), 1251-1259; https://doi.org/10.24976/Discov.Med.202638207.99

(This article belongs to the Special Issue Novel Biomarkers and Therapeutic Targets for Chronic Diseases in Precision Medicine)

Impaired Viability Improvement and Suppression of Ferroptosis and Mitochondria Dysfunction in DHEA-Treated Ovarian Granulosa Cells in Polycystic Ovary Syndrome by HMGB1 Deficiency via Nrf2 Activation

Yuhong Yang, Lin Ma, Jian Huang, Ting Feng

DM 2026, 38(207), 1260-1273; https://doi.org/10.24976/Discov.Med.202638207.100

GNG4 Promotes Lung Adenocarcinoma Progression by Enhancing mRNA Stability via m6A Methylation to Suppress the cGAS-STING Pathway

Jun Ma, Jianghong Li, Xin Wang, Yi Wang, Jie Ma

DM 2026, 38(207), 1274-1290; https://doi.org/10.24976/Discov.Med.202638207.101

G Protein-Coupled Estrogen Receptor Expression Can Predict Poorer Outcomes of EGFR-TKI Treatment for Lung Adenocarcinoma With Malignant Pleural Effusion: A Retrospective Study

Yuansheng Du, Yiguo Ai, Xingxing Wang, Chunling He, Xuqing Wen

DM 2026, 38(207), 1291-1302; https://doi.org/10.24976/Discov.Med.202638207.102

Correlation Between Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol Ratio and Complete Blood Count and Coagulation Parameters, and Their Relationship With Severity and Prognosis of Early-Onset Coronary Artery Disease

Yumin Zhang, Jing Li, Xinkui Wang, Xinfeng Wang

DM 2026, 38(207), 1303-1310; https://doi.org/10.24976/Discov.Med.202638207.103

TRIM34 Accelerates Cardiac Fibrosis by Regulating the SMAD7 Transcription Through HNRNPL Ubiquitination

Yan Huang, Bingying Wang

DM 2026, 38(207), 1311-1326; https://doi.org/10.24976/Discov.Med.202638207.104