Volume 38, Issue 205 (February 2026)

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Discovery Medicine

Print ISSN: 1539-6509Online ISSN: 1944-7930

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Volume 38, Issue 205 (February 2026)

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Autophagy in Post-Ischemic Brain Neurodegeneration: Friend, Foe, or Both?

Ryszard Pluta, Marzena Ułamek-Kozioł

DM 2026, 38(205), 319-334; https://doi.org/10.24976/Discov.Med.202638205.27

Targeted Therapy Resistance in Genitourinary Cancers: From Molecular Mechanisms to Clinical Strategies

Alcides Chaux

DM 2026, 38(205), 335-342; https://doi.org/10.24976/Discov.Med.202638205.28

Prognostic Value and Biological Functions of Neuropilin-1 in Gynecological Cancers: A Narrative Review

Han Jiang, Man Chen

DM 2026, 38(205), 343-356; https://doi.org/10.24976/Discov.Med.202638205.29

(This article belongs to the Special Issue Exploring the Tumor Microenvironment: Innovations and Challenges in Enhancing Immunotherapy Efficacy)

Advances in Understanding SIRT3's Relationship With Metabolic Diseases and Related Cardiovascular Complications

Hai Yu, Yi Luo, Ziyue Zhu, Tingting Yu, Jing Xu

DM 2026, 38(205), 357-367; https://doi.org/10.24976/Discov.Med.202638205.30

Immunotherapy in Cholangiocarcinoma: Can We Turn the Tide Against This Silent Killer?

Xiaofeng Tang, Hechen Huang, Jun Yu, Jian Wu

DM 2026, 38(205), 368-388; https://doi.org/10.24976/Discov.Med.202638205.31

(This article belongs to the Special Issue Exploring the Tumor Microenvironment: Innovations and Challenges in Enhancing Immunotherapy Efficacy)

The Potential Role of Aromatase Inhibitors in Radiation-Induced Morphea Development in Breast Cancer Survivors

Samantha Carranza, Rebecca Olsen, Erin Onken, Heidi David, Neha Dhaliwal, Damini Patel, Amal Umerani, Rayaan Bashir

DM 2026, 38(205), 389-398; https://doi.org/10.24976/Discov.Med.202638205.32

Sevoflurane Inhibits the Progression of Gallbladder Cancer Through Activating Endoplasmic Reticulum Stress and Reducing Glycolysis by Downregulating ROCK1

Yuwen Lao, Dong Zhao, Lei Zhang, Shuangjiang Li, Huayan Lv

DM 2026, 38(205), 399-409; https://doi.org/10.24976/Discov.Med.202638205.33

Systemic Immune-Inflammation Index as a Novel Biomarker for Differentiating Stage III and IV Periodontitis: A Propensity Score-Matched Retrospective Study

Yi Wu, Dandan Zhang

DM 2026, 38(205), 410-418; https://doi.org/10.24976/Discov.Med.202638205.34

Investigation of the Effects of Occlusal Reconstruction on Neural Function and Pain Alleviation in Rats

Jie Cui, Weiwen Li, Azirrawani Ariffin, Muzaimi Mustapha, Rosmaliza Ramli

DM 2026, 38(205), 419-429; https://doi.org/10.24976/Discov.Med.202638205.35

The Effect of Increased HSF1-HMOX1 Expression in H9C2 Cardiomyocytes Following Hypoxia/Reoxygenation on Myocardial Ferroptosis and M1 Polarization of Macrophages

Zicheng Wang, Shengjie Wang, Da Gao, Liangrong Zheng

DM 2026, 38(205), 430-442; https://doi.org/10.24976/Discov.Med.202638205.36

Propofol Ameliorates Neuroinflammation and Oxidative Stress in High-Fat Diet-Induced Rats via Regulation of the AMPK/mTOR Pathway

Siqi Ye, Ke Yan, Lei Li, Qiao Xu

DM 2026, 38(205), 443-452; https://doi.org/10.24976/Discov.Med.202638205.37

C-X-C Motif Chemokine Ligand 8: A Promising Prognostic Biomarker for HPV 16-Driven Cervical Cancer

Yan Li, Huiying Li, Li Shi, Ying Cui

DM 2026, 38(205), 453-467; https://doi.org/10.24976/Discov.Med.202638205.38

(This article belongs to the Special Issue Novel Biomarkers and Therapeutic Targets for Chronic Diseases in Precision Medicine)

CaMKIα-Driven Regulation of the AMPK/SIRT3 Pathway in Controlling Inflammatory Responses During Acute Lung Injury

Lina Zheng, Bin Zhang, Lingzhi Zhao, Pengfei Zhang

DM 2026, 38(205), 468-481; https://doi.org/10.24976/Discov.Med.202638205.39

Independent Determinants of Diagnostic Delay in Female Patients With Axial Spondyloarthritis and Its Impact on 12-Month Disease Outcomes

Hongcheng Zhao, Zhijia Shen, Jinyong Zhao, Guanyu Yang, Bohan Zhang, Xin Huang, Wenhao Wang, Huilin Yang

DM 2026, 38(205), 482-490; https://doi.org/10.24976/Discov.Med.202638205.40

Function and Mechanism of SLC38A5 in Retinoblastoma Development

Chao Wu, Yan Deng, Xiaoyan Xiong, Ying Lu, Xiaolong Yin

DM 2026, 38(205), 491-504; https://doi.org/10.24976/Discov.Med.202638205.41

Capsaicin Improves Fatty Acid Oxidation in Skeletal Muscle Cells Through the TRPV1/TFEB-Dependent Lipophagy Enhancement

Lijuan Wang, Yihua Zhang, Shuyun Wang, Li Li, Yingru Hu, Ying Chang, Zhidan Luo

DM 2026, 38(205), 505-519; https://doi.org/10.24976/Discov.Med.202638205.42

ANO1 Facilitates Maladaptive Cardiac Hypertrophy Through Ferroptosis Regulation: A New Therapeutic Axis Revealed

Lina Hou, Songjian Xin, Wenyao Yu

DM 2026, 38(205), 520-530; https://doi.org/10.24976/Discov.Med.202638205.43

Associations of Dietary UPF Intake With Abdominal Ultrasonic Parameters and Glycemic Parameters in T2DM Patients With Abdominal Obesity

Dongying Nie, Xueyong Lou

DM 2026, 38(205), 531-539; https://doi.org/10.24976/Discov.Med.202638205.44

From Methylation to Mitochondrial Collapse: Unraveling the CTCF-EP300/MTHFD2 Pathway in Sepsis-Induced Acute Kidney Injury

Weike Hu

DM 2026, 38(205), 540-552; https://doi.org/10.24976/Discov.Med.202638205.45

PDK4 and RGMA as Biomarkers for Gastric Cancer Diagnosis and Prognostication: Transcriptomic and Mendelian Randomization Analyses

Mengwei Tu, Mengxue Wang, Zhuo Zhen, Xie Liu, Jianbo Zhang

DM 2026, 38(205), 553-573; https://doi.org/10.24976/Discov.Med.202638205.46

Oxaliplatin Combined With a PD-1 Inhibitor Synergistically Suppresses Gastric Cancer Growth via STEAP4-Mediated Ferroptosis

Yuxiu Zou, Fengxue Dai, Li Feng, Xiaoqiong Jia

DM 2026, 38(205), 574-586; https://doi.org/10.24976/Discov.Med.202638205.47

Computed Tomography-Based Radiomics Model for Predicting KIT Exon 11 Codons 557–558 Deletion Mutation in Gastrointestinal Stromal Tumors

Caijuan Zhang, Qing Song, Jingyu Wang, Dong Dong, Weiling Xu

DM 2026, 38(205), 587-596; https://doi.org/10.24976/Discov.Med.202638205.48

The Role of Chromatin Regulator-Related Genes GADD45A and TAF5 in Polycystic Ovary Syndrome: A Bioinformatics Analysis

Lifeng Gao, Yali Xi, Hongyu Ren, Xiaoxia Wen, Xiangyun Kong, Qi Xie, Xiaowei Huangfu, Dan Lu, Yang Deng

DM 2026, 38(205), 597-608; https://doi.org/10.24976/Discov.Med.202638205.49

Breast Tumor-Secreted APOO Promotes Macrophage Polarization Towards the M2 Phenotype via ADCK2

Jingya Wang, Rong Fu, Qi Yan, Xuan Zhang, Xingjiang Li, Mingxiu Kong, Kaiqi Zhang, Lili Wang

DM 2026, 38(205), 609-622; https://doi.org/10.24976/Discov.Med.202638205.50

Role of the Periaqueductal Gray in Autonomic and Electrocardiographic Alterations During Subarachnoid Hemorrhage With Intraventricular Extension: A Systematic Review

Salvatore Marrone, Benjamin De Ornelas, Erika Gentile, Noemi La Porta, Francesca Graziano, Lorenzo Scalia, Ignazio Alessio Gueli, Silvia Trifirò, Giuseppe Vadalà, Elena Cortese, Chiara Corso, Claudia Rita Vecchio, Antonio Massimo Di Mauro, Gianluca Ferini, Giuseppe Emmanuele Umana, Gianluca Scalia

DM 2026, 38(205), 623-643; https://doi.org/10.24976/Discov.Med.202638205.51

Why Obesity Worsens Bronchial Asthma—The Bioactive Lipids Connection

Undurti N Das

DM 2026, 38(205), 644-648; https://doi.org/10.24976/Discov.Med.202638205.52