Volume 37, Issue 203 (December 2025)

Mechanisms of Inflammation and Divergent Immune Response in Meniere Disease

Jose A. Lopez-Escamez, Pablo Cruz-Granados

DM 2025, 37(203), 2829-2844; https://doi.org/10.24976/Discov.Med.202537203.236

Diagnostic and Prognostic Values of Hypercalcemia in Patients With Breast Cancer Presenting to the Emergency Department: A Narrative Review

Ziqing Zhang, Hongling Wang, Xiangning Lu, Jiaze Xu, Wenqi Ji, Juanjuan Zhang

DM 2025, 37(203), 2845-2853; https://doi.org/10.24976/Discov.Med.202537203.237

Progress in Risk Assessment and Treatment of Carotid Artery Atherosclerosis

Zhijian Li, Zhihao Zhang, Yuan Li, Dongfeng Guan

DM 2025, 37(203), 2854-2862; https://doi.org/10.24976/Discov.Med.202537203.238

Molecular Evaluation of MDR1 Gene Variations and Their Association With Imatinib Resistance in Chronic Myeloid Leukemia Patients

Osama M. Al-Amer, Nora T. Alsharif, Nouf F. Alghabban, Faris J. Tayeb, Mamdoh Moawadh, Mohammed I. Alasseiri, Abdullah Hamadi, Jameel Barnawi, Atif Abdulwahab A. Oyouni, Rashid Mir, Saravanan Muthupandian

DM 2025, 37(203), 2863-2873; https://doi.org/10.24976/Discov.Med.202537203.239

Igniting Metastasis: CCR1 Promotes Lung Cancer Dissemination Through an ERK/c-FOS-RhoGDIβ Axis

Jun Ying, Jiaojiao Ren, Danfei Zhou, Jiangdong Li, Shanshan Hu, Haijian Liu

DM 2025, 37(203), 2874-2885; https://doi.org/10.24976/Discov.Med.202537203.240

Application of Metagenomic Next-Generation Sequencing (mNGS) in Pathogen Detection of BALF in Patients With Acute Exacerbation of Bronchiectasis

Yangyi Jin, Jindun Ding, Xuewen Jin

DM 2025, 37(203), 2886-2894; https://doi.org/10.24976/Discov.Med.202537203.241

Investigation of Molecular Mechanisms Associated With Primary Aldosteronism Based on Transcriptome Sequencing

Heng Zhu, Qinke Li, Qi Huang, Chengwei Zhang, Meng Jia, Chunmei Liu, Qi Wu, Jinchen He

DM 2025, 37(203), 2895-2906; https://doi.org/10.24976/Discov.Med.202537203.242

Exploring the Effects of Maslinic Acid on Gallstone Formation and Liver Injury via the PPAR Signaling Pathway

Shuo Feng, Zhenghao Huang, Fenghe Hang, Chao Shi, Dongxu Lu, Haoran Ding, Tianming Liu, Liwei Liu, Xianzhi Meng

DM 2025, 37(203), 2907-2922; https://doi.org/10.24976/Discov.Med.202537203.243

Possible Correlation Between Serum PDCD4 Levels and Hypothalamic Inflammation in Obesity

Junjie Lu, Qineng Gong, Donghai Shao, Zhenhua Gong, Dongmei Zhang, Feng Zhou

DM 2025, 37(203), 2923-2931; https://doi.org/10.24976/Discov.Med.202537203.244

Role of USP16 in Aβ1–42-Induced Alzheimer's Disease: Targeting IFI16 to Alleviate the Inflammatory Response

Bo Cui, Yan Ding, Cunjiang Li

DM 2025, 37(203), 2932-2941; https://doi.org/10.24976/Discov.Med.202537203.245

Association Between the Triglyceride-glucose-body Mass Index and Acute Kidney Injury Following Cardiac Surgery Under Cardiopulmonary Bypass: A Retrospective Cohort Study

Pingxiong Zeng, Yingling Zhong, Weichang Wang, Jingdan Deng, Weixiong Lin

DM 2025, 37(203), 2942-2951; https://doi.org/10.24976/Discov.Med.202537203.246

Mechanistic Insights Into Caveolin-1-Mediated Upregulation of Dynamin-2 in Podocyte Endocytosis During Diabetic Nephropathy

Xiangjing Wang, Yuanying Xia, Chengli Lou, Xiaoping Fan, Yijing Zhou, Kai Chen

DM 2025, 37(203), 2952-2965; https://doi.org/10.24976/Discov.Med.202537203.247

Inhibition of eIF2α Phosphorylation Enhances the Sensitivity of Renal Cell Carcinoma Cells to Sorafenib-Induced Ferroptosis

Lihang Yu, Chuanchuan Zhan, Jiajun Yan, Ke Gao, Chong Shen, Yu Ren

DM 2025, 37(203), 2966-2977; https://doi.org/10.24976/Discov.Med.202537203.248

FRZB Attenuates Ferroptosis and Oxidative Stress in Diabetic Cardiomyopathy by Modulating the AMPK/PGC-1α Signaling Pathway: A Novel Cardioprotective Mechanism

Zhangyin Zhao, Yinfeng Jia, Xuqing Hou

DM 2025, 37(203), 2978-2989; https://doi.org/10.24976/Discov.Med.202537203.249

Ursolic Acid Ameliorates Osteoporosis via Gut Microbiota Remodeling and Enrichment of Probiotic Species

Morong Wu, Zhengsheng Bao, Jingyuan Wen, Longkang Cui, Gaobo Shen, Xuefeng Li, Bingbing Zhang, Lixia Jin, Yang Yu

DM 2025, 37(203), 2990-3002; https://doi.org/10.24976/Discov.Med.202537203.250

CNN-Based Deep Learning for MRI-Assisted Classification of Benign and Malignant Prostate Nodules: A Diagnostic Performance Study

Tianchang Guo, Xiaomei Zeng, Caiyun Wu, Chongyue Cai, Qiwei Xu, Ruihua Yao, Yuzhi Liang

DM 2025, 37(203), 3003-3012; https://doi.org/10.24976/Discov.Med.202537203.251

GDF11 Mitigates Severe Acute Pancreatitis-Associated Intestinal Injury by Enhancing CD25⁺FOXP3⁺ Regulatory T Cell Function

Jing Chen, Mingyuan Li, Mengting Ma, Wenjie Sheng, Yujiao Shi, Jiaqi Lan, Yuexin Sun, Feixiang Duan

DM 2025, 37(203), 3013-3023; https://doi.org/10.24976/Discov.Med.202537203.252

LTBP3 Affects Acute Myocardial Infarction by Regulating Macrophage Polarization in Cardiac Fibroblasts

Huiying Sui, Lanchun Sun, Hongyu Rao, Tingting Sun, Liru Liu

DM 2025, 37(203), 3024-3035; https://doi.org/10.24976/Discov.Med.202537203.253

ANXA1 Treats Acute Aortic Dissection by Suppressing Macrophage Infiltration and NCF1-Induced Vascular Smooth Muscle Cell Apoptosis

Yingjian Ye, Qianqian Zhang, Guangwen Lu

DM 2025, 37(203), 3036-3050; https://doi.org/10.24976/Discov.Med.202537203.254

Impact of Aberrant CLDN18.2 Expression on Intercellular Junction Stability in Gastric Cancer Cells

Wenxi Li, Mingkai Chen, Biao Qian, Xiao Li

DM 2025, 37(203), 3051-3063; https://doi.org/10.24976/Discov.Med.202537203.255

Development of a 5-year Recurrence Risk Prediction Model After Conservative Surgery for Adenomyosis Based on Clinical and Imaging Features

Anna Shen, Xueqin Cao, Leilei He

DM 2025, 37(203), 3064-3072; https://doi.org/10.24976/Discov.Med.202537203.256

Protective Effect of ATP6V1B2 Against Kanamycin-Induced Cochlear Damage in Mice

Lianrong Wu, Wensi Huang

DM 2025, 37(203), 3073-3082; https://doi.org/10.24976/Discov.Med.202537203.257

DARS2 Attenuates Pathophysiological Characteristics and Apoptosis in Temporal Lobe Epilepsy Rats by Targeting Nrf2 Pathway

Jie Ding, Jiankang Huang, Hongbo Wen, Pengyu Ding, Jingjing Liu, Peng Wang

DM 2025, 37(203), 3083-3094; https://doi.org/10.24976/Discov.Med.202537203.258

Protective Effects of Propofol on Acute Kidney Injury Through Suppressing Ferroptosis and Inflammatory Responses in Renal Tubular Epithelial Cells

Jie Li, Huanhuan Zhang

DM 2025, 37(203), 3095-3106; https://doi.org/10.24976/Discov.Med.202537203.259

It Takes Two to Click: Host Immune Profiles Are Critical Determinants of Effective Immunotherapy Responses

Afsar U. Ahmed

DM 2025, 37(203), 3107-3110; https://doi.org/10.24976/Discov.Med.202537203.260