Volume 37, Issue 202 (November 2025)

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Discovery Medicine

Print ISSN: 1539-6509Online ISSN: 1944-7930

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Volume 37, Issue 202 (November 2025)

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Regulatory T Cells and the Evolution of Immune Tolerance: From Thymic Selection to CAR-Treg Therapies

Mark Rhoge, Nour Younis, Jamil Azzi

DM 2025, 37(202), 2488-2496; https://doi.org/10.24976/Discov.Med.202537202.209

Leukotrienes Implications in Diabetes and Diabetes Complications: A Narrative Review

Mihai Nechifor, Cristina Gales

DM 2025, 37(202), 2497-2513; https://doi.org/10.24976/Discov.Med.202537202.210

Functional Integration of Genetically Engineered Porcine Heart–Kidney Grafts in Rhesus Macaques: A Preclinical Model of Multiorgan Xenotransplantation

Licheng Yan, Zhi Dou, Chi Zhang, Jinfeng Wu, Liefu Ye, Jun Li, Lihua Lei, Fuli Wen, Haifeng Chen, Gang Chen, Hua Cao, Xijie Wu

DM 2025, 37(202), 2514-2529; https://doi.org/10.24976/Discov.Med.202537202.211

Enhancing Ischemic Stroke Diagnosis Using Transferrin-Conjugated Iodine Contrast Agent Liposomes: A Comparative Computed Tomography Angiography Study

Huiling Yang, Liuqing Yang, Jian Yang, Wenzhe Zhao, Dan Li

DM 2025, 37(202), 2530-2538; https://doi.org/10.24976/Discov.Med.202537202.212

Modulating STAT3 Signaling by Selective C5aR1 Inhibition: An In Silico Directed In Vitro Approach to Combat Diabetic Kidney Disease

Ayed A. Dera, Mesfer Al Shahrani

DM 2025, 37(202), 2539-2551; https://doi.org/10.24976/Discov.Med.202537202.213

α-Syn-Induced mTOR Activation Impairs Autophagy and Mitophagy: Unraveling a Novel Mechanism in Parkinson's Disease Progression

Di An, Xiaoxi Liu, Ying Li, Yixian Li, Shasha Zhu

DM 2025, 37(202), 2552-2566; https://doi.org/10.24976/Discov.Med.202537202.214

DNMT3B Silencing Inhibits Malignant Phenotype of Breast Cancer by Suppressing FBXO31 Methylation

Jun Li, Shan Huang, Zhun Zhang, Lei Cai, Yanguang Wen

DM 2025, 37(202), 2567-2578; https://doi.org/10.24976/Discov.Med.202537202.215

PHLDA2 Drives Malignant Progression in Lung Adenocarcinoma via ELK1-Mediated Transcriptional Activation

Fei Ming, DaiPing Zhang

DM 2025, 37(202), 2579-2588; https://doi.org/10.24976/Discov.Med.202537202.216

Pachymic Acid Protects Against Doxorubicin-Induced Cardiotoxicity Through Multi-Pathway Modulation of Oxidative Stress, Inflammation, DNA Damage, and Apoptosis

Yanxi Shi, Daxin Wang

DM 2025, 37(202), 2589-2601; https://doi.org/10.24976/Discov.Med.202537202.217

Enhanced Anti-tumor Activity of iC9/CAR-19/IL-15-Transduced CB-NK Cells Combined With PD-1 Inhibitor Treatment in B-Cell Lymphoma

Yanli Lai, Lixia Sheng, Jiaping Wang, Guifang Ouyang, Shasha You, Zhouning Lin

DM 2025, 37(202), 2602-2613; https://doi.org/10.24976/Discov.Med.202537202.218

Application Effect of Diclofenac Sodium Combined With Eperisone on Managing Lumbar Disc Herniation

Kun Yong, Haoxia Yang, Zhenfeng Liu

DM 2025, 37(202), 2614-2623; https://doi.org/10.24976/Discov.Med.202537202.219

AURKA Knockdown Induces Apoptosis in Human Lung Cancer Cell Lines A549 and H1299 by Regulating Mitochondrial Function and Reactive Oxygen Species

Xinde Wang, Lijun Xie

DM 2025, 37(202), 2624-2636; https://doi.org/10.24976/Discov.Med.202537202.220

ADRB2 Overexpression Reverses Plasma Gelsolin-Induced TGF-β1 Upregulation in Mesangial Cells of IgA Nephropathy

Changsong Han, Yujiang Chen, Kun Wang, Chunlin Chen, Mao Yang, Chuanhui Sun

DM 2025, 37(202), 2637-2648; https://doi.org/10.24976/Discov.Med.202537202.221

From Silencing to Differentiation: SOCS3 Knockdown as the Key to MSC Conversion Into Cardiomyocytes

Yagang Ding, Sibin Guan, Heqin Wang, Mingkui Gao, Qinchuan Li, Bangde Xue

DM 2025, 37(202), 2649-2659; https://doi.org/10.24976/Discov.Med.202537202.222

Diagnostic Value of Hand-Drawn Navigation-Guided Transbronchial Precision Bronchoalveolar Lavage Combined With mNGS in Community-Acquired Pneumonia

Sida Chen, Shan Xiao, Na Li, Chunxing Ye, Yuting Lai, Ling Wen, Yan Shen

DM 2025, 37(202), 2660-2672; https://doi.org/10.24976/Discov.Med.202537202.223

TMAVA Exacerbates Coronary Heart Disease via BBOX-Mediated Mitochondrial Dysfunction

Zhen Ma, Dong Wu, Wenguang Liu, Yingjie Guo, Bin Ning

DM 2025, 37(202), 2673-2686; https://doi.org/10.24976/Discov.Med.202537202.224

IL-25 Attenuates Rheumatoid Arthritis via Inhibition of the TLR4/NF-κB/NLRP3 Signaling Pathway

Jinyue Lu, Jiayao Hao, Jianxiong Zheng, Haiyang Liao, Chunhua Liu, Haili Shen

DM 2025, 37(202), 2687-2701; https://doi.org/10.24976/Discov.Med.202537202.225

Myricetin Mitigates Angiotensin II-Induced Atrial Fibrillation by Alleviating Endoplasmic Reticulum Stress-Induced Autophagy Through Inhibition of ESR1 Ubiquitination

Laisha Yan, Kechao Zhao, Lina Chen, Shunying Zhao

DM 2025, 37(202), 2702-2711; https://doi.org/10.24976/Discov.Med.202537202.226

Symptom Clusters and Quality of Life in Liver Cancer Patients Undergoing Targeted Immunotherapy: A Prospective Longitudinal Cohort Study

Bing Han, Mengxia Qi, Lin Huang, Wen Wang, Shumin Cai, Meiying Huang, Dan Mou, Chunju Cao

DM 2025, 37(202), 2712-2730; https://doi.org/10.24976/Discov.Med.202537202.227

Fluorofenidone Attenuates Silica-Induced Pulmonary Fibrosis: Insights Into Its Mechanism of Action

Lujuan He, Jinyang Wu, Zezhi Zhou, Jing Long, Shenggang Liu

DM 2025, 37(202), 2731-2743; https://doi.org/10.24976/Discov.Med.202537202.228

STAT6 Overexpression Attenuates Parkinson's Disease Pathology Through mTOR Activation

Xiaoqing Ma, Xiaoming Shi, Yu Li, Ling Cong, Hongbo Yao, Qi Lu, Yinan Tian

DM 2025, 37(202), 2744-2757; https://doi.org/10.24976/Discov.Med.202537202.229

Prognostic Value of IKK/NF-κB Pathway Activation in Hepatocellular Carcinoma: A Retrospective Study

Xihan Chen, Shuang Luo, Rujie Zhang, Lulu Zhang

DM 2025, 37(202), 2758-2764; https://doi.org/10.24976/Discov.Med.202537202.230

PTPRO Deficiency Alleviates Ulcerative Colitis by Increasing the Treg/Th1 Ratio Through JAK2-STAT5 Pathway Activation

Xianlan Zhu, Xujin Chen, Ruyi Huang, Lin Ji, Jiale Lv, Wenying Tian, Cheng Yang, Mingming Wang, Lijuan Xu

DM 2025, 37(202), 2765-2785; https://doi.org/10.24976/Discov.Med.202537202.231

FOSL1-ANKRD22 Transcriptional Axis Regulates Mitochondrial Homeostasis to Drive Colorectal Cancer

Xiaojun Zhang, Yutian Zhao, Qiaoling Xu, Shuai Li, Peipei Shen, Yu Xu

DM 2025, 37(202), 2786-2802; https://doi.org/10.24976/Discov.Med.202537202.232

Association of Hypoxia-Inducible Factor-1 Alpha (C1772T) Polymorphism With Hematological Indices in Sickle Cell Anemia Patients From Taif City

Amal F. Gharib, Elham Mohammad Ali, Wejdan Mustafa Barnawi, Hayaa M. Alhuthali, Mazen Almehmadi, Mamdouh Allahyani, Tamer M. Abdelrahman, Rehab A. Karam

DM 2025, 37(202), 2803-2811; https://doi.org/10.24976/Discov.Med.202537202.233

Hydrogen Sulfide Promotes Angiogenesis and Is Associated With Sonic Hedgehog Signaling Pathway Activation After Focal Cerebral Ischemia in Rats

Haiyan Chen, Bingbing Qin, Pin Zheng, Guixin Yang, Ting Wu, Jie Wang, Jianmin Huang, Xuebin Li

DM 2025, 37(202), 2812-2826; https://doi.org/10.24976/Discov.Med.202537202.234

Commentary on “Impact of Altitude on Erythrocyte Sedimentation Rate: A Cross-Sectional Study Using National Laboratory Data From Saudi Arabia”

Jozélio Freire de Carvalho

DM 2025, 37(202), 2827-2828; https://doi.org/10.24976/Discov.Med.202537202.235