Volume 37, Issue 200 (September 2025)

Glioblastoma Multiforme: Navigating Treatment, Recent Breakthroughs and Therapies

Allison B. Reiss, Shelly Gulkarov, Ariel Z. De Leon, Ankita Srivastava, Aaron Pinkhasov, Joshua De Leon, Sara Haddock, Dimitris G. Placantonakis

DM 2025, 37(200), 1721-1744; https://doi.org/10.24976/Discov.Med.202537200.150

(This article belongs to the Special Issue Exploring the Tumor Microenvironment: Innovations and Challenges in Enhancing Immunotherapy Efficacy)

Genetic Alterations in Multiple Myeloma: Implications for Prognosis and Advances in Diagnostic Approaches

Flavia Carbone, Bruna Daraia, Clorinda Maria Luisa Derosa, Pamela Pinto, Angela Maria Moramarco, Giuseppe Lenoci, Claudia Denapoli, Amanda Caruso, Francesco Gaudio, Stefano Martinotti

DM 2025, 37(200), 1745-1754; https://doi.org/10.24976/Discov.Med.202537200.151

(This article belongs to the Special Issue Molecular Mechanisms and Biomarkers in Multiple Myeloma and Lymphoma)

Application of Musculoskeletal Ultrasonography in the Diagnosis of Rheumatic Immune Diseases

Xuyan Shao, Juan Liu, Fang Lai

DM 2025, 37(200), 1755-1762; https://doi.org/10.24976/Discov.Med.202537200.152

The Role of Epitope/Antigen Spreading in CAR T-cell Immunotherapy

John Maher, Kieran Maher

DM 2025, 37(200), 1763-1775; https://doi.org/10.24976/Discov.Med.202537200.153

Role of Vitamin D3 in Patients With Primary Sjögren's Syndrome: Links to Disease Severity and Immune Function

Lixuan Yang, Jianchun Mao

DM 2025, 37(200), 1776-1786; https://doi.org/10.24976/Discov.Med.202537200.154

The Intestinal Microbiota: An Environmental Effector for the Endocannabinoid System and Medicinal Cannabis in Inflammatory Bowel Disease

Luis Vitetta, Debbie Oldfield, Michael Thomsen

DM 2025, 37(200), 1787-1799; https://doi.org/10.24976/Discov.Med.202537200.155

TES7832-Mediated Selective Inhibition of the Scavenger Receptor Cysteine-Rich Domain of the Transmembrane Protease Serine 2/ERG Gene Fusion—A Novel and Potential Approach for Suppressing the ERG-Driven Prostate Cancer

Majed Al Fayi, Ayed A. Dera

DM 2025, 37(200), 1800-1814; https://doi.org/10.24976/Discov.Med.202537200.156

ATF2 Promotes Preeclampsia Accompanied by Gestational Hypertension via Transcriptionally Activating ARRDC3 to Suppress Trophoblast Functions

Shuxia Wu, Aiwen Miao, Chen Zhang, Shanshan Li, Gaoxiang Huo

DM 2025, 37(200), 1815-1823; https://doi.org/10.24976/Discov.Med.202537200.157

Integrative Transcriptomic Profiling Identifies the GATA3-PRF1 Axis as a Mediator of rTMS-induced Attenuation of Neuropathic Pain After Spinal Cord Injury

Qi Zhu, Yibin Zhang, Yao Ouyang, Yanfei Wu, Qian Lv, Wei Zhang

DM 2025, 37(200), 1824-1837; https://doi.org/10.24976/Discov.Med.202537200.158

Progranulin Inactivates PI3K/AKT/mTOR Signaling Pathway to Promote Orthodontic Compression Force-induced Autophagy and Osteogenic Differentiation in Periodontal Ligament Stem Cells

Jing Ye, Xinyan Sun, Xinxin Liu, Yang Jiao

DM 2025, 37(200), 1838-1848; https://doi.org/10.24976/Discov.Med.202537200.159

Trefoil Factor 3 Knockdown Promotes Autophagy and Mitigates Cardiac Hypertrophy and Fibrosis via the CXCR4/JAK/STAT Signaling Pathway

Juan Liu, Yongsheng Li, Zhongcheng Wei, Hailang Liu

DM 2025, 37(200), 1849-1859; https://doi.org/10.24976/Discov.Med.202537200.160

PTBP1 Enhances Epithelial-Mesenchymal Transition by Upregulating HOXA9 to Drive Pancreatic Cancer Progression

Jun Ni, Qi Luo, Xiaowei He, Jin Liu, Ni Zhang

DM 2025, 37(200), 1860-1873; https://doi.org/10.24976/Discov.Med.202537200.161

A Prognostic Model for Acute Myeloid Leukemia Based on Immunogenic Cell Death-Related Genes

Guocai Li, Yaqin Gong

DM 2025, 37(200), 1874-1884; https://doi.org/10.24976/Discov.Med.202537200.162

Autophagy-Mediated B Lymphocyte Dysfunction in the Pathogenesis of IgG4-Related Disease

Boyuan Sun, Yuxue Nie, Yu Peng, Xin He, Jingna Li, Ruijie Sun, Nianyi Zhang, Linyi Peng, Yunyun Fei, Jiaxin Zhou, Wen Zhang

DM 2025, 37(200), 1885-1895; https://doi.org/10.24976/Discov.Med.202537200.163

Galectin-3 Preserves Intestinal Barrier Function via Regulation of the JAK2/STAT3 Signaling Pathway During Ischemia-Reperfusion Injury in Mice

Weilai Yu, Zhixiang Lin, Liwei Xue, Qiu Chen, Siwei Xue

DM 2025, 37(200), 1896-1913; https://doi.org/10.24976/Discov.Med.202537200.164

Osteoprotegerin Promotes Fracture Healing by Enhancing Chondrocyte Differentiation and Activation of the TGF-β Signaling Pathway

Chengbo Wu, Xing Lu

DM 2025, 37(200), 1914-1927; https://doi.org/10.24976/Discov.Med.202537200.165

Mitochondrial Metabolic Dysfunction and Immunization in Thyroid Eye Disease: New Insights From Bioinformatics and Machine Learning

Changjun Wang, Kai Jin, Ji Shao, Jingyi Wang, Jingxin Zhou, Juan Ye

DM 2025, 37(200), 1928-1943; https://doi.org/10.24976/Discov.Med.202537200.166

Larger Circular Staplers Improve Anastomotic Alignment and Reduce Leakage Risk in Esophagectomy

Huiwen Miao, Haobin Jiang, Xiao Teng, Xiayi Lv

DM 2025, 37(200), 1944-1949; https://doi.org/10.24976/Discov.Med.202537200.167

Effects of the BET Family Inhibitor JQ1 on Autophagy and Neuroprotection in Intracerebral Hemorrhage Rat Models: The Role of BRD4

Guo-qing Wang, Jia-jia Xia, Jie Sun, Jian-ying Shi, Li-jing Zhang, Ye-qiong Liu, Jie Liu, Yi-bing Peng

DM 2025, 37(200), 1950-1960; https://doi.org/10.24976/Discov.Med.202537200.168

Dissecting the Role of CKAP2L in Ovarian Cancer: Insights Into Cellular Dynamics and Immune Microenvironment Regulation

Ziyao Ren, Junnan Li, Zhouliang Yang, Hongkai Shang

DM 2025, 37(200), 1961-1973; https://doi.org/10.24976/Discov.Med.202537200.169

HDAC1 Facilitates the Proliferation and Glycolysis in Diffuse Large B-Cell Lymphoma by Modulating PI3K/AKT/mTOR Pathway

Yanzheng Wang, Yan Wang, Shishu Wang, Furong Zhao, Xinmei Yuan, Xiujie Fan

DM 2025, 37(200), 1974-1990; https://doi.org/10.24976/Discov.Med.202537200.170

Galectin-3 Mediates Ischemia-Reperfusion Injury Through Regulation of Oxidative Stress, Inflammation, and the TFAM/PPARβ Axis

Tingting Liu, Jing Wang

DM 2025, 37(200), 1991-2005; https://doi.org/10.24976/Discov.Med.202537200.171

ASAP3 Inhibits RAC1 Activation and Mediates Mitochondria-Endoplasmic Reticulum Crosstalk to Attenuate Myocardial Ischemia-Reperfusion Injury

Ziyang Yu, Yirong Teng, Hongbo Yang, Yudi Wang, Xichen Li, Lei Feng, Wenbo Xu, Yanping Li, Yinglu Hao

DM 2025, 37(200), 2006-2018; https://doi.org/10.24976/Discov.Med.202537200.172

Sanguinarine Inhibits VEGF-Induced Cell Migration and Angiogenesis Through Regulating E-Cadherin and p27 Signal Pathway

Li Ying, Wei Li, Sa Shen, Chongsheng Zhang, Yangyang Zhang, Xiaotian Zhang, Wenan Wang

DM 2025, 37(200), 2019-2031; https://doi.org/10.24976/Discov.Med.202537200.173

Distribution Characteristics and Diagnostic Significance of Nestin in Stromal Components of Pleomorphic Adenoma of the Parotid Gland

Jian-xin Guo, Liang-cheng Tang, Fang Xu, Dao-chun Wang, Xiao-lan Han

DM 2025, 37(200), 2032-2040; https://doi.org/10.24976/Discov.Med.202537200.174

The E3 Ubiquitin Ligase MIB2 Exacerbates Sepsis-Associated Acute Kidney Injury by Promoting GPX4 Degradation-Mediated Ferroptosis and Mitochondrial Dysfunction

Lihua Tang, Feng Zhou, Yufei Wang, Yuxia Jiao

DM 2025, 37(200), 2041-2054; https://doi.org/10.24976/Discov.Med.202537200.175

Th2-Mediated IL-4/PI3K Activation as a Therapeutic Target for Olfactory Dysfunction in Chronic Rhinosinusitis

Jinxiong Yang, Dong Wang, Shihan Liu, Renjing Luo, Wenlong Luo

DM 2025, 37(200), 2055-2064; https://doi.org/10.24976/Discov.Med.202537200.176

Pancytopenia Followed by Mucormycosis-Related Cavernous Sinus–Orbital Apex Syndrome After Chimeric Antigen Receptor T-Cell Therapy: A Case Report

Zi Wang, Chun Lei Li, Dao Bin Zhou, Wei Zhang

DM 2025, 37(200), 2065-2071; https://doi.org/10.24976/Discov.Med.202537200.177