Volume 37, Issue 198 (July 2025)

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Discovery Medicine

Print ISSN: 1539-6509Online ISSN: 1944-7930

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Volume 37, Issue 198 (July 2025)

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Pathogenesis and Regulatory Mechanisms of Tumors—Insights From Thalassemia and Thyroid Cancer

Christos Savvidis, Efthymia Kallistrou, Dimitra Ragia, Eleni Kouroglou, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias

DM 2025, 37(198), 1146-1158; https://doi.org/10.24976/Discov.Med.202537198.103

Pathogenesis and Treatment of Idiopathic Membranous Nephropathy

Shengnan Zeng, Ying Li

DM 2025, 37(198), 1159-1175; https://doi.org/10.24976/Discov.Med.202537198.104

Emerging Role of Gut Microbiome and Risk of Developing Colorectal Cancer and Its Implications in Treatment

Rashid Mir, Shrooq Albarqi, Wed Albalawi, Ghaida Alanazi, Shouq S Alsubaie, Razan I Alghaban, Hanadi Saud Alanazi, Meshari Faisal Alenazi, Alaa Albogmi, Othman R. Alzahrani, Reema Almotairi

DM 2025, 37(198), 1176-1199; https://doi.org/10.24976/Discov.Med.202537198.105

Expert Consensus on Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest in China

Gengzhou Wei, Feier Song, Baojuan Liu, Wenqiang Jiang, Bei Hu, Guoqiang Zhang, Xin Li

DM 2025, 37(198), 1200-1211; https://doi.org/10.24976/Discov.Med.202537198.106

The Impact of High-Intensity Noise on Liver Damage in Septic Rats

Wangyun Fu, Mingli Xu, Mei Song, Can Peng, Fujian Yan

DM 2025, 37(198), 1212-1220; https://doi.org/10.24976/Discov.Med.202537198.107

Knockdown of SIN3A Derepresses SYNPO2 Transcription and Inhibits Gastric Cancer Cell Progression

Fen Feng, Longqing Cheng, Qihua Xu, Jing Wu, Lirong Zhao, Wei Wang

DM 2025, 37(198), 1221-1235; https://doi.org/10.24976/Discov.Med.202537198.108

Significance of Pulse Oximetry Monitoring in the Early Prediction of Respiratory Distress Syndrome in Neonates With Low Birth Weight

Ling Chen, Xian-Qiu Yang, Bo Jiang

DM 2025, 37(198), 1236-1242; https://doi.org/10.24976/Discov.Med.202537198.109

Recognizing the Role of Galectin-9 in Chronic Lymphocytic Leukemia: Insights Into Its Combination With Other Disease Parameters to Jointly Determine Chronic Lymphocytic Leukemia Activity

Przemysław Piwowarczyk, Agata Szymańska, Sylwia Chocholska, Michał Zarobkiewicz, Justyna Woś, Waldemar Tomczak, Jacek Roliński, Agnieszka Bojarska-Junak

DM 2025, 37(198), 1243-1262; https://doi.org/10.24976/Discov.Med.202537198.110

DTX3L Promotes Intrahepatic Cholangiocarcinoma Progression Through P53 Ubiquitination-Mediated Inhibition of ER Stress and Apoptosis

Haoming Lan, Jun Hu, Linsheng Huang, Xianfeng Sheng, Meng Zhou, Shuo Yang, Gan Zhang

DM 2025, 37(198), 1263-1273; https://doi.org/10.24976/Discov.Med.202537198.111

Construction of a Prognostic Model for Sepsis-Induced Acute Lung Injury Based on Neutrophil Extracellular Traps and Key Inflammatory Genes

Wenxing Zhang, Wen Tang, Zhao Li, Juncai Lu, Zhengyu Li, Jichao Peng, Xiaoran Liu

DM 2025, 37(198), 1274-1296; https://doi.org/10.24976/Discov.Med.202537198.112

E2F1 Silencing Enhances Cisplatin-induced Apoptosis and DNA Damage in Retinoblastoma: CENPE Overexpression as a Compensatory Mechanism

Yating Liu, Qingsong Yang, Sizhen Li, Zixiu Zhou, Xinyi Huang, Min Fu

DM 2025, 37(198), 1297-1313; https://doi.org/10.24976/Discov.Med.202537198.113

Activation of TGF-β Smad Signaling Promotes Temporomandibular Joint Injury Repair in Aged Rats

Ruixue Tian, Yun Guo, Xiaosong Zou, Xiaofei Xie, Jie Li, Yue Du, Xiaomiao Lu

DM 2025, 37(198), 1314-1323; https://doi.org/10.24976/Discov.Med.202537198.114

Combining MRI With Color Doppler Ultrasound Enhances Early Diagnosis of Neonatal Hypoxic-Ischemic Encephalopathy

Kun Zheng, Lan Ren, Juan Peng, Hui Li, Xuelian Feng, Ruibo Zhang

DM 2025, 37(198), 1324-1330; https://doi.org/10.24976/Discov.Med.202537198.115

Integrated Multi-Cohort Analysis of Whole-Genome and Transcriptome Data Reveals Interplay Between Metabolism and Methylation in Myelodysplastic Syndrome

Waseem Alzamzami, Sael Alatawi

DM 2025, 37(198), 1331-1345; https://doi.org/10.24976/Discov.Med.202537198.116

Solanine Mitigates Cisplatin Resistance in Lung Cancer via Modulation of the Beclin1-YAP1 Pathway

Nengfu Chen, Pingping Chen, Ningfeng Dai

DM 2025, 37(198), 1346-1358; https://doi.org/10.24976/Discov.Med.202537198.117

Activation of TRPV4 Downregulates TGF-β1 Protein Levels to Promote M1 Polarization of BV-2 Microglia and Induce Apoptosis in HT22 Neuronal Cells

Ting Zhou, Ronggui Zhang, Chao Yang, Jianfang Wei, Ying Feng

DM 2025, 37(198), 1359-1371; https://doi.org/10.24976/Discov.Med.202537198.118

Bone Marrow Mesenchymal Stem Cells Inhibit Ferroptosis Through Mitochondrial Transfer and Improve Endothelial Cell Dysfunction

Guangkuo Wang, Shangqian Li, Fang Li, Zhigang Zhang

DM 2025, 37(198), 1372-1384; https://doi.org/10.24976/Discov.Med.202537198.119

Mechanisms of Loxo-305 in Treating Rheumatoid Arthritis by Dual Inhibition of B Cell Activity and Osteoclast Differentiation

Xuena Wang, Lianjie Cheng, Aihua Liu

DM 2025, 37(198), 1385-1398; https://doi.org/10.24976/Discov.Med.202537198.120

High-Cholesterol Diet Induces Dyslipidemia, Inflammation, Plaque Instability, and Vascular Remodeling in ApoE^-/- and Wild-Type Mice

Wenrong Wang, Yaozhi Qi, Pingjuan Ni, Chen Cheng, Yanan Chen, Jie Lu, Pinjing Hui

DM 2025, 37(198), 1399-1408; https://doi.org/10.24976/Discov.Med.202537198.121

Complement Inhibition Expands the Therapeutic Window of Amyloid-β Immunotherapy in Alzheimer's Disease

Manoj Kumar Pandey

DM 2025, 37(198), 1409-1415; https://doi.org/10.24976/Discov.Med.202537198.122

Bispecific Antibodies in Gastric Cancer Therapeutics: New Hope for High Efficacy and Tolerability

Ioannis A. Voutsadakis

DM 2025, 37(198), 1416-1421; https://doi.org/10.24976/Discov.Med.202537198.123

A Response to: ‘Biological Therapy and Oral Surgery: Safety Recommendations and Practices’

Jozélio Freire de Carvalho

DM 2025, 37(198), 1422-1422; https://doi.org/10.24976/Discov.Med.202537198.124