Volume 37, Issue 197 (June 2025)

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Discovery Medicine

Print ISSN: 1539-6509Online ISSN: 1944-7930

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Volume 37, Issue 197 (June 2025)

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Unveiling Prognostic and Diagnostic Biomarkers in Knee and Hip Osteoarthritis: A Targeted Review

Sergiu Andrei Iordache, Adrian Cursaru, Bogdan Serban, Irina Anca Eremia, Corneliu Ovidiu Vrancianu, Marian Constantin, Sergiu Stanciu, Florin Catalin Cirstoiu

DM 2025, 37(197), 960-975; https://doi.org/10.24976/Discov.Med.202537197.86

A Review Article: Evaluation of the Frequency of Genetic Mutations in Leukemia

Abdullah Hamadi

DM 2025, 37(197), 976-983; https://doi.org/10.24976/Discov.Med.202537197.87

Robust and Specific Association Between Seizure at Presentation and Improved Survival in Patients With Primary Brain Tumors

Alec G. Chen, Truong H. Do, Kai Y. Chen, Ping Zhu

DM 2025, 37(197), 984-993; https://doi.org/10.24976/Discov.Med.202537197.88

Molecular Characterization and Impact of the Genetic Variants GSTP1, LncRNA H19, TCF7L2 and HNF1A on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study

Pradeep Kumar Dabla, Rashid Mir, Mohammad Fahad Ullah, Vimal Mehta, Jamsheed Javid, Imadeldin Elfaki, Eram Hussain, Jameel Barnawi, Mohammed M. Jalal, Malik A. Altayar, Ruqaiah I. Bedaiwi, Syed Khalid Mustafa

DM 2025, 37(197), 994-1010; https://doi.org/10.24976/Discov.Med.202537197.89

Harnessing the Power of Chlorogenic Acid: Inhibiting IL-2-Mediated Treg Upregulation to Combat Post-Traumatic Osteomyelitis

Yongpei Lin, Zhoutong Wu, Yan Ni, Ye Zhong, Leming Liao, Sai Yu

DM 2025, 37(197), 1011-1022; https://doi.org/10.24976/Discov.Med.202537197.90

Mechanism of AGT-Mediated Magnesium Ion Uptake in Age-Related Olfactory Dysfunction

Dong Wang, Jinxiong Yang, Bo Liu, Wenlong Luo

DM 2025, 37(197), 1023-1032; https://doi.org/10.24976/Discov.Med.202537197.91

Impact of Unilateral Chemical Injury on Contralateral Unaffected Eyes: A Clinical and Experimental Study

Dan Wu, Jun Xiang, Jing Zhang, Yiqin Dai, Lijia Tian, Jianjiang Xu

DM 2025, 37(197), 1033-1048; https://doi.org/10.24976/Discov.Med.202537197.92

Hypoxia-Induced Up-Regulation of ACSS2 Drives the PI3K/AKT/mTOR Pathway Through HMGCS1 to Enhance the Proliferation and Stemness of Pancreatic Cancer Cells

Zhangcheng Zhao, Gengyu Li, Beibei Zhang, Yuansen Zhang

DM 2025, 37(197), 1049-1061; https://doi.org/10.24976/Discov.Med.202537197.93

Protective Role of Quercetin in Chronic Atrophic Gastritis: Modulation of Gastric Mucosal Integrity via the Transforming Growth Factor-beta1/Smads Signaling Pathway

Peipei Cai, Qingqing Song, Fangpeng Ye, Rongjian Chen, Zhixiang Lin

DM 2025, 37(197), 1062-1073; https://doi.org/10.24976/Discov.Med.202537197.94

Improved Sampling Method to Enhance the Positive Rate of HER2 Detection in Gastric Cancer

Huan Shi, Li-qing Liu, Yue-hong Qin, Xi-lin Song, Xiao-wen Wen, Long-gang Wang, Bing Liu, Xu Sun, Jie Chai, Shi-jiang Wang, Kai Liu

DM 2025, 37(197), 1074-1081; https://doi.org/10.24976/Discov.Med.202537197.95

Combined Oral Contraceptives Modulate Apoptosis via IL-11/PI3K/AKT Pathway in Rat With Premature Ovarian Insufficiency

Meiling Chen, Fan Zhang, Fang You, Li Zhang, Li Zeng

DM 2025, 37(197), 1082-1095; https://doi.org/10.24976/Discov.Med.202537197.96

Amygdalin Alleviates Airway Inflammation and Remodeling in Asthma Mice: Involvement of TGF-β1/Smads Signaling Pathway

Jing Zhao, Yamei Wang, Haixu Wang

DM 2025, 37(197), 1096-1104; https://doi.org/10.24976/Discov.Med.202537197.97

Inhibiting NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis: A New Role of GADD45B's Role in Hypertriglyceridemia-Induced Acute Pancreatitis

Shengang Zhou, Yingge Xu, Jianfeng Tu, Mao Zhang

DM 2025, 37(197), 1105-1116; https://doi.org/10.24976/Discov.Med.202537197.98

S100A8 Mediates Autophagy and Apoptosis in Ovarian Cancer Cells via the PI3K/Akt Pathway

Xiaojie Ma, Yu Wu, Guanyu Cao

DM 2025, 37(197), 1117-1129; https://doi.org/10.24976/Discov.Med.202537197.99

Computed Tomography Imaging for the Diagnosis of Primary Sarcomatoid Carcinoma of the Lung: A Case Report

Li-Feng Xu, Xi-Sheng Zhou, Feng Chen, Ping Zhu

DM 2025, 37(197), 1130-1138; https://doi.org/10.24976/Discov.Med.202537197.100

Bridging the Translational Gap: Prioritizing the Spontaneous Canine Osteoarthritis Model for Preclinical Studies

Khan Sharun, Shajahan Amitha Banu, Luca Melotti

DM 2025, 37(197), 1139-1142; https://doi.org/10.24976/Discov.Med.202537197.101

The Urgent Need to Assess and Prevent the Deposits of Microplastics and Nanoplastics in Our Brain

Mario Manto, Jerome R. Lechien

DM 2025, 37(197), 1143-1145; https://doi.org/10.24976/Discov.Med.202537197.102