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The Role of The Tumor Protein P53 in Disease and Its Mechanisms of Drug Resistance
Editor: Annapina Russo

Submission Deadline: 31 July 2024 (Status: Open)

Special Issue Editor(s)

Prof. Annapina Russo      Email   |   Website
Department of Pharmacy, School of Medicine and Surgey, University of Naples Federico II, Naples, Italy
Interests: post-transcriptional regulation of gene expression; ribosomal proteins; ribosome biogenesis; tumorigenesis; chemotherapy; multidrug resistance

Special Issue Information

Dear Colleagues,

Colloquially known as a “guardian of the genome,” p53 plays a key role in coordinating cellular responses to genotoxic stress, regulating the expression of different genes, and forming a complex regulatory network for cellular homeostasis.

Since its discovery, many cellular functions have been ascribed to p53, including transcription regulation, signaling for DNA repair, cell cycle arrest, cellular development and differentiation, metabolism, as well as apoptosis and senescence. The development of most tumors is linked to the alterations of p53 signaling pathways. In addition, loss or mutations of p53 are claimed to confer drug resistance to tumors.

According to a growing number of studies, however, p53 appears to play a more significant part in the biological and pathological mechanisms that have far-reaching impacts on human health and diseases, including but not limited to Alzheimer’s and Parkinson’s diseases.

This Special Issue welcomes original research or review papers describing recent advances in understanding the role of p53 function and dysfunction in human diseases, with an emphasis on molecular mechanisms underlying the p53-driven drug resistance, and in identifying new therapeutic targets to develop innovative approaches for targeted strategies.

Prof. Annapina Russo
Guest Editor


ribosomal proteins; p53; chemotherapy; drug resistance; cell cycle arrest; cell death

Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.

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